Inside all mammals is an intricate network of receptors that play important roles in health, healing, and homeostasis. The endocannabinoid system (ECS) was discovered in the early 1990s, but evolutionary evidence indicates that some version of an ECS has existed in all vertebrates (as well as sea squirts and nematodes) for at least 600 million years, suggesting that these receptors and the substances that bind to them play a crucial role in the functioning of life. There are three main receptors associated with the ECS: CB1, CB2, and TRPV1. According to Raphael Mechoulam, the chemist who first isolated THC in the 1960s, these receptors are most abundant in the brain and they are not found everywhere – they persist in specific areas that are involved in important bodily processes like coordination & movement, emotions, memory, reduction of pain, and reproduction. CB1 was discovered in 1990 and is cited as one of the most common receptors found in the brain, again a testament to this system’s key role in neurological processes. CB2 was the second receptor to be discovered. It is largely found in immune cells, although it can be found in other parts of the body including the digestive system and peripheral nervous system. TRPV1 is involved in pain response, inflammation, and regulation of body temperature. It is known as the attachment site for capsaicin – the compound responsible for the burning sensation we associate with chili peppers.
The receptors mentioned above are nothing without the substances that attach to and activate them – the endogenous cannabinoids that our bodies produce. The most studied of these endocannabinoids are AEA (nicknamed anandamide after the Sanskrit word for “bliss”) and 2-AG. Both can attach to CB1 and CB2, although AEA prefers CB1 and 2-AG prefers CB2. Dustin Sulak, an Osteopath who uses cannabis in his practice, describes these endocannabinoids as keys that open the same locks (receptors). Depending on which keys are used, the locks will open to different doors. This system, which is responsible for maintaining various bodily processes, can become imbalanced in various ways: receptors can be over or under active, and endocannabinoid levels can be too low or too high.
Health Benefits of PCR Hemp Oil
1. Helps maintain normal emotional balance and calmness
2. Supports immune system function
3. Supports a healthy inflammatory response
4. Helps maintain a healthy intestinal tract
Holistic Hound Hemp Oil is organically grown in Colorado and is unflavored for easy administration to dogs and cats!